HLA loss
HLA loss refers to the loss of mismatched Human Leukocyte Antigen (HLA) alleles by leukemic cells after allogeneic stem cell transplantation. This immune escape mechanism can result in relapse, especially in haploidentical and unrelated donor settings. Detecting HLA loss is crucial in research focused on post-transplant dynamics and immune evasion. GenDx supports such studies with the HLA-KMR® assay, a qPCR-based solution for sensitive detection of genomic HLA loss, available for Research Use Only.