Ins & outs of novel allele submission: a users perspective

HLA genes are highly polymorphic. With the development of Next-Generation Sequencing (NGS) and its ability to type HLA genes at a high resolution level, more and more new alleles are identified. When encountering new or extended alleles, the sequences can be submitted to the IPD-IMGT/HLA database.

In this webinar, Niels Kouprie, Senior Technician at the Laboratory for Transplant Immunology, University Medical Center Groningen, will guide you through the process of submitting a new allele to the IPD-IMGT/HLA database. Mr. Kouprie is already working in the field of HLA typing for more than 30 years and has been involved in the introduction of GenDx Sequencing Based Typing and later Next Generation Sequencing in his lab. Altogether, Mr. Kouprie is responsible for more than 100 new allele submissions to the IPD-IMGT/HLA database.

Attend the webinar and receive 0.15 continuing education credits (CECs).

New features in NGSengine

In this webinar, we guided you through the newest NGSengine features (version 2.17) and described the latest important software improvements.
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Towards defining the immunogenicity of HLA eplets

Epitope-based HLA-matching has emerged as a promising strategy to improve solid organ transplant (SOT) outcome. Functional units of HLA epitopes are called ‘eplets’.  Mismatched eplets on donor HLA can be defined be comparing the tertiary protein structure of donor- and recipient-HLA, on the basis of 2-field HLA typing results.
An unmet need so far is the definition of the immunogenicity of each individual eplet. Our research group in Basel/Switzerland has investigated the immunogenicity of eplets using the human pregnancy as a model.
The two speakers discuss current concepts to define the immunogenicity of HLA eplets and share their experiences from their own study.