Category: On-Demand Webinars

Generally, deceased donor typing is carried out using intermediate-resolution HLA-typing methodologies. Achieving high-resolution typing across HLA-loci before transplantation could significantly improve donor organ allocation and virtual crossmatching, as it aligns resolution between HLA antibody definition and HLA typing. Offering benefits particularly for highly-sensitised recipients.

In this webinar, Lizzy Russell-Lowe, Clinical Scientist at Manchester Royal Infirmary, will present a study in which HLA typing results obtained with the GenDx NGS-Turbo® kit, using Oxford Nanopore Technologies sequencing, were retrospectively compared with standard intermediate-resolution HLA typing methods. The NGS-Turbo® kit produced concordant typing results for all samples in less than 4 hours.

The webinar will explore the clinical utility of having high-resolution typing available in a deceased-donor setting, and the feasibility of achieving this in a timely manner.

Could HLA typing be the missing link in your precision oncology strategy?

During this webinar, we will take you through their recent experiences in HLA Typing and Precision Medicine for Oncology Immunotherapy.

Stephanie Ahrendt, International Medical Science Liaison Manager at Eurobio Scientific, will explore how oncology has evolved from broad treatments to highly personalized care. She will discuss the challenge of tumour heterogeneity and the growing role of biomarkers—such as TAAs and TSAs—in guiding treatment. She will also highlight how HLA polymorphisms are emerging as key predictors of immunotherapy success, and how immunotherapy is helping target cancers that evade immune detection.

Valentina Manzini, Project Coordinator, Companion Diagnostics at GenDx, will introduce the fundamentals of HLA biology and its role in immune recognition. She will explain how HLA typing has advanced—from serology to NGS—and how it’s enabling HLA-restricted therapies like cancer vaccines and adoptive T-cell treatments. Using real-world examples, she will show how HLA typing is becoming a companion diagnostic and shaping the future of personalized immunotherapy.

with Deborah Tsuyuki PhD, Technical Application Specialist at GenDx.

Epitope-based HLA-matching has emerged as a promising strategy to improve solid organ transplant (SOT) outcome. Functional units of HLA epitopes are called ‘eplets’.  Mismatched eplets on donor HLA can be defined be comparing the tertiary protein structure of donor- and recipient-HLA, on the basis of 2-field HLA typing results.
An unmet need so far is the definition of the immunogenicity of each individual eplet. Our research group in Basel/Switzerland has investigated the immunogenicity of eplets using the human pregnancy as a model.
The two speakers discuss current concepts to define the immunogenicity of HLA eplets and share their experiences from their own study.

with guest speaker Dr. Brown, the associate director of the histocompatibility testing laboratory, and assistant professor of pathology and laboratory medicine, at the University of Pennsylvania.

with guest speaker Dr. Luis Hidalgo, associate Professor and Histocompatibility Lab Director at the University of Wisconsin School of Medicine and Public Health.

with guest speaker Dr Eric Spierings, Universitair Medisch Centrum Utrecht, NL.

with guest speaker Prof. Katharina Fleischhauer, Universitatsklinikum Essen, DE