When an organ becomes available, transplant teams are under pressure to act fast, but accuracy in matching is equally critical. Today, most deceased donor HLA typing is still performed at intermediate resolution, which can limit certainty when ruling out donor-specific antibodies (DSAs). As a result, the ability to use virtual crossmatching may be restricted, ultimately slowing down organ allocation for highly-sensitised recipients.
High-resolution typing across HLA loci could help overcome this challenge by bringing typing resolution in line with how HLA antibodies are defined. If performed quickly enough, this could support more confident decision-making and improve the chance that suitable organs are accepted in time.
In our upcoming webinar, Lizzy Russell-Lowe, Clinical Scientist at Manchester Royal Infirmary, will present a study in which HLA typing results obtained with the GenDx NGS-Turbo® kit, using Oxford Nanopore Technologies sequencing, were retrospectively compared with standard intermediate-resolution HLA typing methods. The NGS-Turbo® kit produced concordant typing results for all samples in less than 4 hours.
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Can high-resolution typing be delivered fast enough for deceased donor timelines?
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Could it help reduce reliance on wet crossmatching?
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What might the potential benefits be for highly-sensitised patients?
Learn more in our webinar!
The promising results of the study will be discussed in detail during our upcoming webinar:
NGS-Turbo® is currently available as RUO. Find out more about the product here
