Assessment of immunologic risk in solid organ transplantation is one of the primary functions of an HLA laboratory. The risk assessment is based on the cumulative interpretation of multiple assays used to measure HLA antibodies and the believed understanding of HLA in the allograft. What is not well recognized is the degree of variability in HLA molecules immobilized onto Luminex single antigen beads, variable HLA expression on T and B lymphocytes used in cell-based crossmatches, and biologically encoded differences affecting in vivo HLA expression. Variable HLA expression is therefore inherent across all assays used in HLA laboratories as well as donor HLA targeted by recipient HLA antibodies.
In this webinar, Dr. Hidalgo will provide a brief overview of these concepts and how they impact the interpretation of immunologic risk in transplant recipients. Live chat will be open for your questions or comments
