Chimerism Monitoring

When performing an allotransplantation, donor cells are transferred to a recipient. When successful, the engraftment is maintained, although the recipient may have its own cells present as well as cells from the donor. 

This chimeric state of the transplant is dynamic and a relapse to a diseased state in which recipient cells increasingly return should be avoided. Monitoring the post-transplant chimeric status is important as it could indicate an imminent relapse.

 

Earlier relapse detection with qPCR

To detect a relapse or predict a possible undesirable change in chimeric status, the measurement has to be highly sensitive. When using qPCR as a method of measurement a sensitivity of as low as o.o5% can be realized. This is 20 to 100 fold more sensitive compared to current conventional method using STR's. Overcoming the shortcomings in sensitivity and ease of analysis, we have created KMRtype & KMRtrack reagents together with KMRengine software. The first comprehensive and complete workflow for Chimerism Monitoring by qPCR. 

 

Available as Research Use Only (RUO) and CE

KMRtype® & KMRtrack®
Chimerism Monitoring Reagents
 

  • Reduced lab workflow
  • Simultaneous typing of 8 Samples
  • Multiple donor analysis
  • Compatible with multiple real time thermo cyclers

 

 

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KMRengine®
Chimerism Analysis Software 

  • Automated data analysis
  • Longitudinal data storage and reporting
  • Protocol generation and flexible experiment setup
  • Enables direct importing into LIMS

Read more

HLA-KMR® 

Detection of HLA loss by qPCR

 

 

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