13 January 2020



Webinar on Wednesday,  January 22                             

HLA mismatches between donors and recipients may lead to alloreactivity after transplantation. With the identification of numerous new HLA alleles the risk of alloreactive responses towards HLA mismatches after transplantation has become more challenging to predict. The PIRCHE (Predicted Indirectly ReCognizable HLA Epitopes) algorithm has been developed to estimate the  risk associated to alloreactive T-cell responses. The PIRCHE algorithm addresses the indirect recognition of HLA mismatches. It aims to improve transplant outcome by reducing Graft-versus-Host Disease and by enhancing Graf-versus-Leukemia effects after hematopoietic stem cell transplantation.

We are pleased to welcome our guest speaker Dr Eric Spierings to our webinar. In his position as director of the HLA tissue typing lab at the University Medical Center Utrecht, the Netherlands, he developed the rationale behind PIRCHE®.




  • Role of HLA mismatches and T cells in alloreactivity
  • PIRCHE® technology explained
  • PIRCHE® in NGSengine 2.16 (by GenDx)

Live chat will be open for your questions or comments  


Wednesday,  January 22 

12.00-12.30 pm CET
Amsterdam, NL

12.00-12.30 pm CDT
 Chicago, IL, USA