High sensitivity donor-recipient chimerism monitoring can aid in the diagnosis of leukemia relapse and facilitate timely clinical intervention. When relapse is detected after HLA-mismatched hematopoietic stem cell transplantation (HSCT), it is important to understand whether or not it is characterized by “HLA loss”, ie genomic loss of the mismatched HLA, as this has important implications for the appropriate treatment options.
We are pleased to welcome our guest speaker Prof. Dr. Katharina Fleischhauer to our webinar. As director of the Institute for Experimental Cellular Therapy at the University of Essen, Germany, she will share her knowledge on monitoring HLA-loss relapse by quantitative PCR for patient follow-up after allogeneic HSCT.
Topics to be discussed:
- Immune evasion by HLA-loss explained
- Detection of HLA-loss by qPCR
Live chat will be open for your questions or comments
Tuesday, November 12