Continuation of our business related to the COVID-19 outbreak

Dear customers,

We follow the developing outbreak of COVID-19 closely by monitoring the World Health Organization (WHO) and the Dutch government including the health measures of National Institute for Public Health and the Environment (RIVM) in the Netherlands. In general, we have defined and safeguarded our critical functions where possible and actively minimized physical contacts in our company, e.g. by increasing online cooperation and working in shifts.

The following is important for you to know:

  • Both our Dutch head office and US office are open as usual. You can contact us via our general email address and phone number(s): info@gendx.com and +31 (0)30 252 3799  or +1 (312) 815 5006
  • Our support team remains available for all your questions. Our intention is to answer your questions within 24 hours.
  • We have secured the safety and quality of our products by working in shifts to continue production and logistics.
  • Orders continue to be processed and shipped. Please place your order via order@gendx.com  or your local distributor.
  • All physical contact events in the upcoming month are canceled. We will organize some additional webinars instead, e.g. on April 8th the webinar  Multiplex amplification for fast and easy HLA typing is scheduled – click here for more information and registration

Even during this difficult time, we are happy to assist you and we hope that the potential damage for all our customers may be limited. Please take care of yourself and others, and stay healthy.

Kind regards,

The GenDx Team

May webinar series to commemorate our 15th anniversary

To commemorate our 15th anniversary, we are sharing a series of webinars this year! In the coming weeks we will offer multiple webinars, each taking approximately 30 minutes.

Register for one or multiple webinars via the link(s) below.


Webinar 1: Variability in HLA Expression: Impact on Histocompatibility Assay Interpretation and Immunologic Risk Assessment

May 7, 2020, 3:00 p.m. CEST (Amsterdam time) / noon CST (Chicago time)

We are pleased to welcome our guest speaker, Dr. Luis Hidalgo, to this webinar. Dr. Hidalgo is Associate Professor and Histocompatibility Lab Director at the University of Wisconsin School of Medicine and Public Health.

Register (CEST, Amsterdam)
Register (CST, Chicago)


Webinar 2: Daily practice in an HLA lab: dealing with HLA-DR, a complicated genetic region

May 20, 2020, 3:00 p.m. CEST (Amsterdam time) / noon CST (Chicago time)

We are pleased to welcome our guest speaker, Dr. Nicholas Brown, to our webinar. Dr. Brown is the associate director of the histocompatibility testing laboratory, and assistant professor of pathology and laboratory medicine, at the University of Pennsylvania. Dr. Brown is interested in clinical assays for histocompatibility laboratories and has published reports on NGS typing assays, HLA antibody assays, and crossmatching. In this webinar, he will share his knowledge on the complicated HLA-DR immunogenetics.

Register (CEST, Amsterdam)
Register (CST, Chicago)


Webinar 3:  GenDx case studies *

May 27, 2020, noon CEST (Amsterdam time) / noon CST (Chicago time)

  • Live discussion of NGS data
  • Tips and tricks

Register (CEST, Amsterdam)
Register (CST, Chicago)


* You will receive data files in advance. We ask you to analyze the data and think about what you would report to the clinician. Before the webinar we would like to receive your answers and questions on education@gendx.com so we can address them in the live webinar. (software trial license available upon request)  We look forward to receiving your interpretation of the data!
For each webinar you attend, you will receive 0.15 continuing education credits (CECs).

We are looking forward to virtually meeting you during one or multiple webinars! If you have any questions, please contact us directly via education@gendx.com

Join us for the Tulip Challenge

Are you up for a workout challenge?

As an alternative to the well-known Tulip Run, the sports highlight of the EFI meetings, we invite you to join the Tulip Challenge in May 2020. This challenge can be completed from any city, country and continent in the world and goes beyond running since some preventive measures restrict people to go outside.

Share the workout that keeps you healthy and stay connected with the HLA field, as we used to do with the Tulip Run.

Are you in?

5 Steps to participate in the Tulip Challenge

  • Register before May 15 via: tulip-challenge-2020.eventbrite.co.uk and wait for your welcome package to arrive at your home.*
  • Use the textile marker to write down your city or country on the front of the T-shirt. We also include a card to write down your workout.
  • Run, walk, plank, squat or do another (indoor) workout in May, wearing your special edition Tulip Challenge T-shirt and make a photo or video.
  • Send the photo or video to marketing@gendx.com or share via your social media channel using #tulipchallenge2020. We will publish and/or share your workout on our social media channels to inspire others in the HLA field all around the world to do your workout as well.
  • For every submission, GenDx will donate €25,- to the organizers of the 18th International HLA & Immunogenetics Workshop to support research on COVID-19.

*We have a limited amount of Sports T-shirts available. Register soon to receive this special edition Tulip Challenge Sports T-shirt.

With this challenge we hope you will be encouraged to stay active and fit to overcome this exceptional period, be connected with the HLA family and united by the common goal: to enhance the outcome of transplantation.

Introducing the renewed Custom Lab Service

GenDx is proudly introducing the renewed Custom Lab Service. Empowered by our unsurpassed HLA expertise and advanced high-quality systems, we are fully committed to providing HLA typing services to facilitate HLA research.

Are you a CRO, CDMO, Pharma or a research organization and in need for support of your HLA typing project? You can just send us the DNA you would like to analyze and GenDx will report back the tissue typing results. Turnaround time and follow-up depends on the request.

For more information on our Custom Lab  Service, click here or contact us.

 

EFI postponed until 2021

Covid-19 update: Statement from EFI & BSHI Committees

Due to the COVID-19 pandemic, EFI 2020 has been postponed and will now take place on 

Thursday 22nd April – Sunday 25th April 2021

The postponed conference shall take place at the same venue, SEC Glasgow. Email communications have been sent to all stakeholders.  In order to minimise inconvenience and in anticipation of your questions we have provided some Frequently Asked Questions (FAQs) to assist you.

We look forward to seeing you in Glasgow in April 2021!

Webinar series to commemorate our 15th anniversary

To commemorate our 15th anniversary, we are sharing a series of webinars this year! We believe that continuous education is important for all HLA typers and therefore we have developed the Teaching Session Web Series. In the coming weeks we will offer multiple webinars, each taking approximately 45 minutes.

In the first two webinars we will discuss the principles of the NGS workflow and demonstrate data analysis in NGSengine. In the third and fourth webinar we will deal with challenging case studies for in-depth data analysis and interactive discussions.

Webinar 1: April 14, Basics of the NGS workflow
Webinar 2: April 16, Introduction to NGSengine®
Webinar 3: April 21, GenDx case studies (easy/medium level)
Webinar 4: April 23, GenDx case studies (advanced level)

Do you want to learn more about the NGS workflow, NGSengine, or strengthen your data analysis skills? Register for one or multiple webinars of our Teaching Session Web Series via the link(s) below.


Webinar 1: April 14, 2020, 12:00 PM

Basics of NGS workflow

  • Introduction to high-resolution HLA typing with NGS
  • NGS workflows for HLA typing

Register (CEST, Amsterdam)
Register (CDT, Chicago)


Webinar 2: April 16, 2020, 12:00 PM

Introduction to NGSengine

  • NGSengine software demo
  • Tips and tricks for effective data analysis
  • Demonstration of a GenDx case study

Register (CEST, Amsterdam)
Register (CDT, Chicago)


Webinar 3: April 21, 2020, 12:00 PM

GenDx case studies (easy/medium level)*

  • Live discussion of NGS data
  • Tips and tricks

Register (CEST, Amsterdam)
Register (CDT, Chicago)


Webinar 4: April 23, 2020, 12:00 PM

GenDx case studies (advanced level)*

  • Live discussion of NGS data
  • Tips and tricks

Register (CEST, Amsterdam)
Register (CDT, Chicago)

* You will receive data files in advance. We ask you to analyze the data and think about what you would report to the clinician. Before the webinar we would like to receive your answers and questions on education@gendx.com so we can address them in the live webinar. (software trial license available upon request)  We look forward to receiving your interpretation of the data!
For each webinar you attend, you will receive 0.15 continuing education credits (CECs).

We are looking forward to virtually meeting you during one or multiple webinars! If you have any questions, please contact us directly via education@gendx.com

Webinar 8 April: Multiplex amplification for fast and easy HLA typing

At GenDx we strive for fast and easy sequencing-based HLA typing. Using a multiplexed PCR strategy significantly reduces pipetting steps and hands-on time.

In this webinar, Sake van Wageningen PhD, Project Manager R&D, will present the GenDx multiplexed strategies and give a development update on our latest 11-loci multiplex product. He will also demonstrate how multiplexed data is analyzed in NGSengine.

NEW! Attend the webinar and receive 0.15 continuing education credits (CECs).

More info and registration

 

Meet us at the EWIC 2020

Are you attending the upcoming East West Immunogenetics Conference in Budapest? Join our presentation on Friday, March 6, or meet us at our booth.

“Solving Biological Mysteries with NGS: Three Alleles in One Sample”

by Sebastian Ziemann PhD

Clinical samples that are sent for HLA typing can sometimes contain surprising peculiarities, such as three alleles present in one sample. A situation like this can lead to inexplicable heterozygous or questionable positions that cannot be easily interpreted. Upon receiving a sample like this, we did further investigation to find out what was going on in the sample.

We are looking forward to meeting you in Budapest!

GenDx partners with PIRCHE

Genome Diagnostics B.V. (“GenDx”) announced today that they have entered a collaboration with the Berlin-based company PIRCHE AG and have released a new version of their software NGSengine®. NGSengine, globally considered to be the ultimate Human Leukocyte Antigen (HLA) typing software for multiple NGS platforms, can now export HLA typing results of an individual sample directly to the PIRCHE matching services website. This will facilitate laboratories to predict indirectly recognizable HLA epitopes for either hematopoietic stem cells or solid organs.

About the PIRCHE algorithm
HLA mismatches between donors and recipients may lead to alloreactivity after transplantation. With the identification of numerous new HLA alleles, the risk of alloreactive responses towards HLA mismatches after transplantation has become more challenging to predict. The PIRCHE (Predicted Indirectly ReCognizable HLA Epitopes) algorithm has been developed to estimate the risk associated to alloreactive T-cell responses. The PIRCHE algorithm addresses the indirect recognition of HLA mismatches. It aims to improve transplant outcome by reducing Graft-versus-Host Disease and by enhancing Graf-versus-Leukemia effects after hematopoietic stem cell transplantation and cord blood transplantation. In the field of organ transplantation, the algorithm allows estimating the incidence of developing donor-specific antibodies against the transplant, which is considered the major risk of graft failure.

About High-Resolution HLA Typing
The HLA system consists of a large family of highly variable genes and allelic variants which form the basis of the human immunological defense system. In stem cell transplantation, matching patient and donor is vital as small differences between HLA alleles may have serious effects on the outcome of transplantation. High-resolution typing is a technology which enables determination of variations in nucleotides, making it ideal for stem cell transplantation purposes.
GenDx offers the NGSgo® reagent line and the NGSengine software package for NGS-based HLA typing.

GenDx at EFI 2020 (postponed)

Covid-19 update: Statement from EFI & BSHI Committees

The organisers of EFI 2020, together with the EFI and BSHI Committees, are extremely concerned about the current coronavirus pandemic. As such we are sad to advise that we cannot proceed with the conference as planned in April. We have decided to postpone the conference and associated events.  We hope to have new dates confirmed in the next few days. We will update all stakeholders as soon as we have further information, which should be next week. (Read full statement here).
Meet GenDx during EFI2020
Are you also attending the 34th EFI which will run from the 26th to the 29th of April 2020 in Glasgow?
Make sure to stop by our booth, join our activities and commemorate our 15th anniversary with us!

Teaching Session     
NGS HLA Typing and beyond; Expand your knowledge*
Learn more about the ins & outs of HLA Typing by Next Generation Sequencing.
  • Workflows for NGS platforms
  • Implementation of NGS in the lab
  • Shared experiences of users
  • Data analysis by case studies

Date & Time: Sunday, 26th of April   8:30 – 16:00
Venue: SEC Centre, Room: Carron 1

*ABHI accredited, Attendance is free of charge

Satellite Symposium         
Excellence in Sharing
During this meeting, our two Guest Speakers Prof dr. Christian Seidl (German Red Cross – DRK Bloodbank), and XiangJun Liu PhD (BFR Gene Diagnostic, Beijing) and also Wietse Mulder PhD (CEO, GenDx) and Maarten Penning PhD (CTO, GenDx) will share their knowledge and experiences with you.
Date & Time: Tuesday, April 28th   13:00 – 14:00
Venue: SEC Centre, Room: Alsh
Attendance is free of charge

Tulip Run
Run for the future of immunology
Join the Tulip Run & Walk on Tuesday morning and get your (Golden) Tulip trophy. Sign up and pick up your running shirt at the GenDx Booth. Looking forward to meeting you bright and early!

Date & Time: Tuesday, April 28th   07:00 – 08:00
Meeting point: entrance SEC Centre

Register for the Tulip Run

Participation is free of charge