Dutch Donor Recruitment Day

On Saturday September 19, it is World Marrow Donor Day. On this day all donors are thanked for their willingness to donate (blood) stem cells for patients in need of a transplant.

At GenDx we are closely involved by the need for more stem cell donors. We therefore have initiated the yearly Dutch Donor Recruitment Day since 2018, to give attention to stem cell donation and actively recruit stem cell donors. We organize this in close cooperation with Matchis, the Dutch foundation that enables patients with leukaemia and other severe blood disorders to receive stem cell transplantation. On this day, both GenDx employees and members of Utrecht student sport associations SPIN, Histos, Orca and Triton are committed to inform and recruit new donors.

This year we will not physically be present on the Utrecht Science Park, but inform and motivate potential stem cell donors via our online channels instead.

Are you between 18-35 years old, healthy and motivated to potentially save lives? Visit www.matchis.nl for more information about stem cell donation, requirements, procedures and registration.

Share your health, become stem cell donor!

BLOG: NGSgo®-MX11-3: The multiplex you have been waiting for.

With the launch of our brand new multiplex HLA amplification product NGSgo-MX11-3, it is time to learn and discover more about this unique product! We have asked our Project Managers R&D Sake van Wageningen and Bram Luiken to highlight why MX11-3 is the product you have been waiting for…

Bram and Sake, you have been working on the development of the new Multiplex product of GenDx, called NGSgo®-MX11-3. At the moment, GenDx already has a multiplex in its portfolio, NGSgo®-MX6-1, why should we choose MX11-3?

MX11-3 is the latest addition to the GenDx HLA typing product line and is designed to be the new ‘flagship’ amplification product. The product incorporates a lot of frequently requested updates to our amplification products, greatly extending coverage, increased ease of use and high data quality.

Sounds like an excellent addition to the product line! If our customers order MX11-3, what will they find in the product kit?

The kit contains three highly optimized multiplex amplification primer-sets, each with their own reconstitution buffer for dissolving the primers the first time the kit goes into use. Primers and their corresponding buffer have the same cap colour for ease-of-use.

Additionally, you will find tubes of water and Longmix, the only reagent needed for amplification outside of the primers.

You are referring to three multiplex amplification primer-sets. You might be aware that other companies have all 11 loci in 1 tube. Why did GenDx choose to work with 11 loci in 3 tubes, what are the advantages?

The use of 3 tubes allows optimal data quality by separating amplicons and amplification primers that are most prone to generation of hybrid reads or pseudogene/dimer artefacts. This greatly reduces the noise levels in data analysis and allows high mappability compared to one tube approaches. The aim was to generate a simple protocol with the highest data quality so your patients end up with the best possible typing result.

You mentioned that the product is easy to use. Why?

NGSgo-MX11-3 amplification mixtures consist of only 3 components in easy to handle volumes, while all 11 genes are amplified using a single cycling program. Immediately after amplification, equal volumes of each mix are used for pooling (1:1:1) followed by a fixed volume input of 2µl into the NGSgo library preparation workflow. This means that you do not have to quantify your amplicons. The product is designed in conjunction with NGSgo library preparation and NGSengine® analysis has been optimized to analyse MX11-3 data.  

What about coverage? Is it correct that MX11-3 has whole-gene coverage?

The NGSgo-MX11-3 has an increased coverage as compared to the traditional amplification strategies. It combines optimized versions of previously available AmpX v2 whole gene amplifications for HLA class I, as well as DRB1, DRB3, DQB1, DQA1 and DPB1. New are whole gene amplifications for DRB5 and DPA1 and improved coverage of DRB4 exon2 and 3 in 1 amplicon.

Thank you very much for these interesting insights in the new products MX11-3. Last but not least we are very eager to know, when can we start using MX11-3?

NGSgo®-MX11-3 is expected to be ready for shipment early October, 2020 (RUO). You can already place your order, contact your local GenDx representative for more information.

 

GenDx proud sponsor of ASHI Virtual REW

ASHI Regional Education Workshop have gone virtual! As corporate sponsor, GenDx will give an Innovative Technology Talk on Friday August 28 from 3.30 pm – 3.45 pm, followed by a Q&A. Additionally, we will be happy to (virtually) meet you in the Virtual Exhibit Hall on Friday August 21.

Will we meet you there?

Please have a look at the ASHI regionals website for the full virtual program: http://www.ashiregionals.org/ 
You need to register in order to access the program.

 

Join our webinars in September!

The summer is in full swing! While some are enjoying a well-deserved summer break, others have already enjoyed their holiday and are now keeping the office running.
After a short break in July and August, we will start again with the webinars in September. On September 2 we will kick off with the webinar New features of NGSenginefollowed by the webinar Towards defining the immunogenicity of HLA eplets on September 16.

Attend the webinar and receive 0.15 continuing education credits (CECs).

Stay up-to-date on all our educational events by frequently checking our website: GenDx.com/education. If you have any questions, please contact us directly via education@gendx.com

GenDx and Stadsschouwburg strengthen cooperation

Last week, Wietse Mulder PhD (CEO, GenDx) and Joost Kook (Deputy Director, Stadsschouwburg Utrecht) have signed a new contract for three years to confirm mutual engagement and strengthen their cooperation. Three years ago, GenDx became partner of the Stadsschouwburg Foundation. In the new contract GenDx becomes a founder.

Please find the full press release in Dutch below:

 

GenDx en Stadsschouwburg verstevigen samenwerking

Afgelopen week ondertekenden Wietse Mulder (PhD, CEO van GenDx) en Joost Kok (adjunct-directeur Stadsschouwburg Utrecht) een nieuwe overeenkomst voor drie jaar om de wederzijdse betrokkenheid te bevestigen en de samenwerking te verstevigen. Drie jaar geleden trad GenDx toe als partner van de Stadsschouwburg Foundation. In het nieuwe contract wordt GenDx founder.
De Stadsschouwburg Foundation is een alliantie van Utrechtse organisaties en bedrijven die de schouwburg in staat stellen jaarlijks een aantal exclusieve (en kostbare) producties in het programma op te nemen. Als waardering voor hun steun biedt de schouwburg deelnemers aan de foundation bijzondere faciliteiten zoals ontvangsten van relaties, ontmoetingen tussen founders en diverse vormen van exposure. Andere Founders zijn Douwe Egberts, Rabobank Utrecht e.o. en de Provincie Utrecht.

Wietse Mulder (PhD, CEO van GenDx):
“Drie jaar geleden zijn we partner geworden van de Stadsschouwburg, met het volgende statement: ‘Wij weten wat het betekent om als donor het verschil te maken. Daarom is GenDx partner van Stadschouwburg Utrecht.’
GenDx is een Utrechtse Life Science onderneming en gevestigd op het Utrecht Science Park. In een tijd waarin nagenoeg geen voorstellingen kunnen worden gegeven bij de Stadsschouwburg, willen wij onze betrokkenheid versterken door founder te worden.
De relatie met de stadsschouwburg ligt ons na aan het hart en wordt door onze medewerkers zeer gewaardeerd. Zij kijken er naar uit om weer een voorstelling van eigen keuze bij te kunnen wonen. Daarnaast zijn we een tevreden bezoeker van restaurant Zindering, waar we regelmatig met onze gasten naar toe gaan.”

Joost Kok (adjunct-directeur Stadsschouwburg Utrecht):
“De Stadsschouwburg Foundation is een fijne plek waar veel Utrechtse bedrijven zich thuis voelen. De founders en partners steunen al jaren de activiteiten van Stadsschouwburg Utrecht. Zeker in deze tijd is deze steun hard nodig. We investeren veel in relatiebeheer waarbij het persoonlijke contact voorop staat. Dat dit werkt zien we aan een trouwe partner als GenDx, die nu besloten heeft om founder te worden. Het is hartverwarmend om te zien dat Gendx zoveel vertrouwen in ons uitspreekt, voor nu en in de toekomst.”


Foto:
V.l.n.r.: Joost Kok (adjunct-directeur Stadsschouwburg Utrecht), Wietse Mulder (PhD, CEO GenDx) en Dennis Dercksen (manager sales & sponsoring Stadsschouwburg Utrecht)

Tulip Challenge aftermovie

The Tulip Challenge was initiated during the COVID lockdown period to encourage people to stay fit, be connected with the HLA family and united by the common goal: to enhance the outcome of transplantation.

 

Last May, 87 participants from 14 different countries have completed the Tulip Challenge. Thank you for sharing your photos and videos of unique, impressive and exhausting workouts, which will definitely inspire all of us for the future.

Together, we have raised €2175 which will be donated to the organizers of the 18th International HLA & Immunogenetics Workshop to support research on COVID-19. Next week, the cheque will be handed over to the chairmen Eric Spierings and Sebastiaan Heidt.

Tulip Challenge Dashboard – Week 4

We have come to the end of the Tulip Challenge in May 2020. Thank you all for joining and sharing your workout with us! We are glad that the Tulip Challenge kept us connected with the HLA family during these extraordinary times and that we are united by the common goal: to enhance the outcome of transplantation.

Thanks to 87 completed Tulip Challenge in 14 different countries, we will donate € 2175 to the organizers of the 18th International HLA & Immunogenetics Workshop to support research on COVID-19.
You can check our photo gallery to see all Tulip Challenge workouts that were done by you: gendx.com/2020/05/tulip-challenge-2020/ 

Tulip Challenge 2020

Tulip Challenge Dashboard – Week 3

With the Tulip Challenge we hope you will be encouraged to stay active and fit to overcome this exceptional period, be connected with the HLA family and united by the common goal: to enhance the outcome of transplantation.

The third week has passed, let’s update you about the Tulip Challenge!
Until now, 44 workouts have been completed with a total distance of 1195.75 KM! Not only running and cycling, but also inline skating and downhill mountain biking, HIIT workouts and jump rope workouts. The workouts have been completed in the Netherlands, the US, the UK (Scotland & England), Italy, Spain, Germany and Belgium.

For those of you who haven’t received their package yet, please be patient. Postal services are delayed worldwide and we trust they are doing their very best to deliver the package asap!

With the weekly Tulip Challenge Dashboard, we will keep you informed about the number of workouts completed. Also have a look at the photos of the completed Tulip Challenges in our photo gallery: gendx.com/2020/05/tulip-challenge-2020/ 

Tulip Challenge Dashboard – Week 2

With the Tulip Challenge we hope you will be encouraged to stay active and fit to overcome this exceptional period, be connected with the HLA family and united by the common goal: to enhance the outcome of transplantation.

We are at the end of the second week of the Tulip Challenge, so it’s time for another update!
Until now, 22 workouts have been completed with a total distance of 481 KM! Not only running and cycling, but also inline skating and downhill mountain biking – how cool is that?

For those of you who haven’t received their package yet, please be patient. Postal services are delayed worldwide and we trust they are doing their very best to deliver the package asap!

With the weekly Tulip Challenge Dashboard, we will keep you informed about the number of workouts completed. Also have a look at the photos of the completed Tulip Challenges in our photo gallery: gendx.com/2020/05/tulip-challenge-2020/ 

Tulip Challenge Dashboard – Week 1

With the Tulip Challenge we hope you will be encouraged to stay active and fit to overcome this exceptional period, be connected with the HLA family and united by the common goal: to enhance the outcome of transplantation.

One week has passed since the start of the Tulip Challenge, and we are very pleased with the high number of registrations from all over the world! The first workouts have been completed in the Netherlands, Spain and United States and we can’t wait to receive more photos and videos of completed challenges.

With the weekly Tulip Challenge Dashboard, we will keep you informed about the number of workouts completed. Also have a look at the photos of the completed Tulip Challenges in our photo gallery: gendx.com/2020/05/tulip-challenge-2020/ 

15 years GenDx: ‘Excellence in sharing’

A new decade has started. And, 2020 is a remarkable year as GenDx celebrates its 15th anniversary! ‘Excellence in sharing’ is our theme for 2020. One of the values of GenDx which will get a lot of attention by offering you interesting topics and in depth information related to the HLA field. Keep an eye on our event calendar for webinars and educational events. Visit us during the main congresses or just contact our team to learn more about our continuously expanding product portfolio. We are happy to share our successes with you!