Chimerism Monitoring

When  performing an allotransplantation, donor cells, are transferred to a recipients. When successful, the engraftment is maintained, although the recipient may have its own cells present as well as cells from the donor. 

This chimeric state of the transplant is dynamic and a relapse to a diseased state in which recipient cells increasingly return should be avoided. Monitoring the post-transplant chimeric status is important as it could indicate an imminent relapse.

 

Earlier relapse detection with qPCR

To detect a relapse or predict a possible undesirable change in chimeric status, the measurement has to be highly sensitive. When using qPCR as a method of measurement a sensitivity of as low as o.o5% can be realized. This is 20 to 100 fold more sensitive compared to current conventional method using STR's. Overcoming the shortcomings in sensitivity and ease of analysis, we have created KMRtype & KMRtrack reagents together with KMRengine software. The first comprehensive and complete workflow for Chimerism Monitoring by qPCR. 

 

Available as Research Use Only (RUO)

KMRtype® & KMRtrack®
Chimerism Monitoring Reagents
 

  • Reduced lab workflow
  • Simultaneous typing of 8 Samples
  • Multiple donor analysis
  • Compatible with multiple real time thermo cyclers

 

 

Read more

KMRengine®
Chimerism Analysis Software 

  • Automated data analysis
  • Longitudinal data storage and reporting
  • Protocol generation and flexible experiment setup
  • Enables direct importing into LIMS

Read more

HLA-KMR 
HLA loss detection assay's 

  • Most frequent allele groups of HLA-A, C and DPB1
  • Applicable with KMRtrack protocol
  • Fully integrated with KMRengine

 Read more

Get Support

Have questions about your experiment, data analysis or our products?

 

 

 

 

 

 

Visit our support pages

Laboratory Services

Looking to outsource your HLA typing work, or need advice with setting up your own facility?

 

 

 

 

 

 

Ask advice and service